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Updated: Aug 10, 2026
10:22
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
Hormone allergy
Russell R Roby1, Richard H Richardson, Aristo Vojdani
1Roby Institute, Austin, TX 78746, USA. roby@drroby.com
Summary
This study found high levels of antibodies to estrogen and progesterone in women experiencing hormone-related symptoms. This suggests hormone allergies may contribute to conditions like asthma and migraines.
Area of Science:
- Immunology
- Endocrinology
- Allergy Research
Background:
- Hormone changes in women are linked to symptoms like asthma, migraines, dermatitis, and pain.
- A potential connection exists between hormone-related symptoms and an antibody response to hormones.
Purpose of the Study:
- To investigate the association between hormone changes and antibody responses.
- To explore the role of hormone antibodies in conditions such as pre-menstrual asthma and menstrual migraines.
Main Methods:
- Blood samples were analyzed for IgG, IgM, and IgE antibodies to progesterone and estrogen.
- Samples were collected from healthy control subjects and patients with symptoms related to menstrual cycles.
- Symptoms studied included asthma, migraines, and joint pain.
Main Results:
- A significant number of patients exhibited elevated levels of IgG, IgM, and IgE antibodies to progesterone and estrogen.
- These elevated levels were observed at 2 standard deviations above the mean values of control subjects.
Conclusions:
- Evidence suggests the presence of antibodies to estrogen and progesterone.
- Hormones and their metabolites may act as antigens, promoting antibody synthesis and allergy.
- Identifying and desensitizing hormone allergies could offer new treatment avenues for various disorders.
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