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Related Experiment Videos

Nocturnal oxygenation using a pulsed-dose oxygen-conserving device compared to continuous flow.

Robert L Chatburn1, Joseph S Lewarski, Robert W McCoy

  • 1Respiratory Care Department, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA. robert.chatburn@uhhs.com

Respiratory Care
|March 15, 2006
PubMed
Summary

Pulsed-dose oxygen-conserving devices (PDOCDs) effectively deliver oxygen during sleep, comparable to continuous-flow systems in most patients. Setting PDOCDs based on daytime oxygen saturation ensures adequate nocturnal oxygenation for selected individuals.

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Area of Science:

  • Respiratory Medicine
  • Biomedical Engineering

Background:

  • Pulsed-dose oxygen-conserving devices (PDOCDs) are widely used for ambulatory oxygen therapy.
  • Limited research exists on PDOCD efficacy during sleep.
  • This study compares PDOCDs to continuous-flow oxygen in sleeping patients.

Purpose of the Study:

  • To compare nocturnal oxygen saturation (S(pO2)) and heart rate in patients using PDOCDs versus continuous-flow oxygen.
  • To evaluate the suitability of daytime S(pO2) as a target for PDOCD settings during sleep.

Main Methods:

  • 10 home-oxygen patients were studied.
  • Baseline awake and asleep S(pO2) and heart rate were recorded with continuous-flow oxygen.
  • Patients were switched to a PDOCD, adjusted to match awake baseline S(pO2), and monitored during sleep.

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Main Results:

  • No clinically significant difference in S(pO2) or heart rate was observed between PDOCD and continuous-flow oxygen.
  • PDOCD use resulted in a statistically significant but clinically unimportant S(pO2) decrease (95.7% vs 93.2%).
  • One patient experienced an S(pO2) drop due to inadequate PDOCD triggering sensitivity.

Conclusions:

  • The tested PDOCD model provided comparable oxygenation to continuous-flow oxygen in 9 out of 10 patients during sleep.
  • Daytime S(pO2) on continuous-flow appears to be an appropriate setting target for PDOCDs during sleep.
  • Results are specific to the tested device and patient selection; further research on diverse populations and devices is warranted.