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Related Experiment Videos

First trimester screening for Down syndrome in multiple pregnancy.

Jane Cleary-Goldman1, Richard L Berkowitz

  • 1Columbia University Medical Center, New York, NY 10032, USA. jec32@columbia.edu

Seminars in Perinatology
|March 15, 2006
PubMed
Summary

First trimester screening for Down syndrome is a promising option for high-risk pregnancies involving multiples. This approach offers advantages for prenatal diagnosis in patients with twins, triplets, or more.

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Prenatal Diagnosis

Background:

  • The incidence of multiple births (twins, triplets, high-order multiples) has risen significantly in the past 20 years.
  • This increase is attributed to assisted reproductive technologies and delayed childbearing.
  • Prenatal diagnosis in multiple gestations presents unique challenges with limited screening test options.

Purpose of the Study:

  • To review the advantages of first-trimester screening for Down syndrome in pregnancies with multiples.
  • To highlight the potential of early screening in a high-risk obstetric population.

Main Methods:

  • This paper reviews existing literature and clinical data on first-trimester screening protocols for Down syndrome.
  • Focus is placed on adaptations and efficacy in multiple gestations.

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Main Results:

  • First-trimester screening demonstrates potential as a viable option for detecting Down syndrome in pregnancies with multiples.
  • Early screening can provide valuable information for risk assessment in this demographic.

Conclusions:

  • First-trimester screening offers a promising approach to prenatal diagnosis for Down syndrome in patients carrying multiples.
  • Further research and protocol refinement are beneficial for optimizing outcomes in high-risk multiple pregnancies.