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Updated: Aug 10, 2026
Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model
Published on: December 8, 2023
Physiological response to superantigen-adsorbing hemoperfusion in toxin-concentration-controlled septic swine
Keishi Miwa1, Mayumi Fukuyama, Naoto Matsuno
1New Frontiers Research Laboratories, Toray Industries, Inc., Kanagawa, Japan. Keishi_Miwa@nts.toray.co.jp
Background/Aims:
Superantigens are suspected of being potent initiators of gram-positive sepsis, and new therapies for superantigen elimination are required. The effects of hemoadsorption with a superantigen-adsorbing device (SAAD) were evaluated in septic swine.
Methods:
Toxic shock syndrome toxin-1 (TSST-1) was infused, and blood concentration was maintained at the clinical level for 6 h. Endotoxin was then infused to induce lethal shock. All animals were hemoperfused with SAAD or a control column for 8 h and changes in pathological parameters and mortality were examined.
Results:
Animals perfused with SAAD had a highly significant (p < 0.01) survival advantage compared with control groups at 24 h after initiation of the TSST-1 infusion. SAAD also suppressed the increase in the arteriovenous shunt ratio and decrease of partial arterial oxygen pressure at 6 h after TSST-1 infusion initiation.
Conclusion:
We suggest that there is a potential application of SAAD in treating superantigen-induced respiratory dysfunction and sepsis.
