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Updated: Aug 10, 2026
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Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Management of brain arteriovenous malformations
Chanhung Z Lee1, William L Young
1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco General Hospital, California 94110, USA. clee4@anesthesia.ucsf.edu
Current Opinion in Anaesthesiology
|March 15, 2006
Summary
New risk factors for brain arteriovenous malformation (AVM) hemorrhage, including genetics, are identified. Research explores AVM treatments and protective measures during neurovascular surgery.
Area of Science:
- Neurology
- Neurosurgery
- Vascular Surgery
Background:
- Brain arteriovenous malformations (AVMs) are complex vascular lesions.
- Hemorrhage from AVMs poses significant neurological risk.
Purpose of the Study:
- To review recent findings on factors associated with AVM hemorrhage.
- To discuss current and emerging treatment options for AVMs.
Main Methods:
- Review of recent clinical and genetic studies.
- Analysis of treatment outcomes from microsurgery, radiosurgery, and endovascular techniques.
- Consideration of ongoing trials and novel therapeutic agents.
Main Results:
- Identified risk factors for AVM hemorrhage include age, aneurysms, and genetic factors.
- Microsurgery may worsen neurological function in unruptured AVMs.
- Radiosurgery shows efficacy for deep AVMs but with delayed hemorrhage risk; endovascular cooling offers neuroprotection.
- Tetracyclines show promise in reducing AVM rupture rates.
Conclusions:
- Clinical and genetic factors aid in AVM hemorrhage risk stratification.
- Further research is needed to identify high-risk patients and develop targeted medical therapies for AVMs.
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