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Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
Published on: February 7, 2014
Ambulatory arterial stiffness index: rationale and methodology
Eamon Dolan1, Yan Li, Lutgarde Thijs
1ADAPT Centre and Blood Pressure Unit, Beaumont Hospital, and Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Blood Pressure Monitoring
|March 15, 2006
Summary
A new measure, the ambulatory arterial stiffness index (AASI), derived from blood pressure monitoring may predict cardiovascular mortality. AASI offers prognostic information beyond traditional pulse pressure measurements.
Area of Science:
- Cardiovascular Medicine
- Hypertension Research
- Biomedical Engineering
Background:
- Increased arterial stiffness is an early predictor of cardiovascular disease.
- Pulse pressure, measured by ambulatory blood pressure monitoring (ABPM), indicates arterial stiffness.
- A novel surrogate measure for arterial stiffness may improve cardiovascular risk prediction.
Purpose of the Study:
- To introduce the ambulatory arterial stiffness index (AASI) as a new measure of arterial stiffness.
- To evaluate AASI's potential to predict cardiovascular mortality.
- To compare AASI with pulse pressure as a prognostic marker.
Main Methods:
- Calculated AASI from 24-hour ABPM data in 11,291 patients.
- Defined AASI as 1 minus the regression slope of diastolic vs. systolic blood pressure.
- Correlated AASI with pulse pressure in the study cohort.
Main Results:
- AASI and pulse pressure were higher in women.
- A moderate correlation (0.5) was observed between AASI and pulse pressure.
- AASI is readily obtainable from standard ABPM.
Conclusions:
- Ambulatory arterial stiffness index is a novel, easily derived measure from ABPM.
- AASI may offer additional prognostic value for cardiovascular outcomes.
- This index could enhance cardiovascular risk stratification.
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