Inherited epigenetic variation--revisiting soft inheritance
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Updated: Aug 10, 2026

Analysis of Transgenerational Epigenetic Inheritance in C. elegans Using a Fluorescent Reporter and Chromatin Immunoprecipitation (ChIP)
Published on: May 5, 2023
1Department of Biology, Washington University, 1 Brookings Drive, St Louis, Missouri 63130, USA. richards@biology2.wustl.edu
Abstract:
Phenotypic variation is traditionally parsed into components that are directed by genetic and environmental variation. The line between these two components is blurred by inherited epigenetic variation, which is potentially sensitive to environmental inputs. Chromatin and DNA methylation-based mechanisms mediate a semi-independent epigenetic inheritance system at the interface between genetic control and the environment. Should the existence of inherited epigenetic variation alter our thinking about evolutionary change?
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