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Phrenic neuropathy in arsenic poisoning
S K Bansal1, N Haldar, U K Dhand
1Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Chest
|September 1, 1991
Summary
Acute arsenic neuropathy can affect the phrenic nerve, causing breathing difficulties. Prompt d-penicillamine treatment led to significant recovery in a patient with this rare condition.
Area of Science:
- Neurology
- Toxicology
- Clinical Medicine
Background:
- Arsenic poisoning is a significant environmental health concern.
- Neuropathy is a known complication of acute arsenic exposure.
- Phrenic nerve involvement in arsenic neuropathy is rarely documented.
Observation:
- A patient presented with symptoms suggestive of diaphragmatic dysfunction.
- Clinical examination revealed asymmetric bilateral phrenic nerve compromise.
- Imaging and electrophysiological studies confirmed phrenic nerve dysfunction.
Findings:
- The patient exhibited prolonged phrenic nerve conduction times, confirming nerve damage.
- Arsenic neuropathy was diagnosed based on exposure history and clinical presentation.
- d-penicillamine therapy was initiated to chelate arsenic from the body.
Implications:
- This case highlights the potential for arsenic toxicity to cause severe respiratory compromise.
- Early diagnosis and intervention with chelating agents like d-penicillamine are crucial for recovery.
- Understanding phrenic nerve involvement expands the spectrum of arsenic-induced neurological deficits.