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Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
Published on: October 11, 2019
[How much primaquine is needed to eradicate Plasmodium vivax hypnozoites?]
José Muñoz1, María Velasco, David Alonso
1Sección de Medicina Tropical, Centro de Salud Internacional, Hospital Clínic, Barcelona, Spain. jmunozg@clinic.ub.es
Introduction:
Primaquine is now the only drug available to eradicate Plasmodium vivax malaria. The optimal dose of primaquine to prevent relapses of P. vivax remains under discussion.
Clinical Cases:
We describe three cases of P. vivax malaria from different geographical areas, in which a tolerance to standard doses of primaquine and, in some cases, to much higher doses has been observed.
Comments:
P. vivax tolerance to primaquine is an emerging problem in daily practice. Reassessment of the primaquine dose required to eradicate P. vivax intrahepatic hypnozoites is needed.
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