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Published on: July 4, 2014
The use of surface analysis techniques to determine the route of manufacture of tablet dosage forms
R Mitchell1, N L Marzolini, S A Hancock
1CSMA Ltd, Queens Road, Penkhull, Stoke-on-Trent, ST4 7LQ, UK.
Abstract:
Analytical methods for determining the manufacturing process of tablet dosage forms have not been previously reported. The use of surface analysis techniques in particular X-ray Photoelectron Spectroscopy and Time of Flight Secondary Ionization Mass Spectrometry will be described and a model proposed which allows the prediction of the route of manufacture in calcium phosphate and cellulosic-based tablet formulations. Results of the application of this model to evaluate prototype tablet formulations prepared by wet granulation or direct compression will be reported. Strengths and limitations of the model will be discussed.
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