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Published on: May 6, 2013
Lack of association of type 1 diabetes with the IL4R gene
H Q Qu1, M C Tessier, R Fréchette
1Endocrine Genetics Laboratory, The McGill University Health Center, (Montreal Children's Hospital), Montréal, QC, Canada.
Aims/Hypothesis:
The association between IL4R and type 1 diabetes has been tested in many studies in recent years, with contradictory results. The aim of this study was to re-evaluate the genetic association in type 1 diabetic nuclear families of mixed European background.
Subjects, Materials And Methods:
We genotyped six non-synonymous single-nucleotide polymorphisms (SNPs) of the IL4R gene in 830 nuclear families as specified above, including a French Canadian subset.
Results:
No association between type 1 diabetes and any SNP or haplotype was found by the transmission disequilibrium test.
Conclusions/Interpretation:
Previous positive reports may be due to population stratification as, according to HapMap data, allele frequencies in the IL4R region vary considerably by ethnicity.
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