Related Experiment Video
Updated: May 25, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Impact of carotid artery stenting on plasma interleukin-6, tumor necrosis factor-α and C-reactive protein
1Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University Liaocheng, Shandong Province, PR China.
Insights
Carotid artery stenting (CAS) significantly elevates inflammatory markers like C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). Higher levels are observed in patients with restenosis post-CAS.
Area of Science:
- Cardiovascular Medicine
- Inflammation Research
- Interventional Cardiology
Background:
- Carotid artery stenting (CAS) is a common procedure for atherosclerotic stenosis.
- Inflammatory markers play a crucial role in the pathophysiology of atherosclerosis and post-procedural complications.
- Understanding the inflammatory response to CAS is vital for patient management and risk stratification.
Purpose of the Study:
- To evaluate the impact of CAS on plasma levels of key inflammatory markers: CRP, IL-6, and TNF-α.
- To investigate whether the extent of stenting or the occurrence of restenosis influences these inflammatory markers.
Main Methods:
- Plasma levels of CRP, IL-6, and TNF-α were measured in 61 patients.
- Measurements were taken at multiple time points: pre-CAS, 1 hour, 2 weeks, 1 month, 6 months, and 12 months post-CAS.
- Patient subgroups were analyzed based on the number of stents placed and the presence or absence of restenosis.
Main Results:
- CAS was associated with a significant immediate increase in plasma CRP, IL-6, and TNF-α levels (P<0.05 or <0.01).
- Patients receiving multiple stents or single diffusive lesions exhibited higher inflammatory marker levels compared to those receiving a single stent for a single lesion (P<0.05 or <0.01).
- Elevated CRP, IL-6, and TNF-α levels were observed in patients who developed restenosis (23%) compared to those without restenosis (P<0.05 or <0.01).
Conclusions:
- CAS induces a significant and sustained increase in plasma inflammatory markers.
- Elevated inflammatory markers post-CAS are associated with adverse outcomes, specifically restenosis.
- Monitoring these inflammatory markers may aid in identifying patients at higher risk for restenosis after CAS.
Aim:
This study aimed to investigate the impact of carotid artery stenting (CAS) on plasma levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and C-reactive protein (CRP).
Methods:
The levels of CRP, IL-6, and TNF-α were measured in 61 patients before CAS, 1 h, 2 weeks, 1 month, 6 months, and 12 months after the stenting.
Results:
The levels of CRP, IL-6 and TNF-α increased immediately after CAS (P<0.05 or <0.01). The levels of CRP, IL-6 and TNF-α in patients receiving two stents for multiple lesions or single diffusive lesions was also high than in patients receiving one stent for a single lesion (P<0.05 or <0.01). The levels of CRP, IL-6 and TNF-α in patients with restenosis (14/61, or 23%) were higher than in those without restenosis (P<0.05 or <0.01).
Conclusion:
CAS was associated with a significant increase in plasma CRP, IL-6 and TNF-α. The levels of these inflammatory factors in patients with post-CAS restenosis were higher than in those without restenosis.
