Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Therapy for recurrent acute pericarditis: a rheumatological solution?

A Brucato1, G Brambilla, Y Adler

  • 1Department of Rheumatology, Internal Medicine and Emergency Medicine, Ospedale Niguarda, Milan, Italy.

Clinical and Experimental Rheumatology
|March 17, 2006
PubMed
Summary

A multidrug protocol significantly reduces recurrent pericarditis attacks. Colchicine enhances treatment effectiveness, though good control is achievable even without it.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recurrent pericarditis in children: Clinical and therapeutic differences from adults.

International journal of cardiology·2026
Same author

Is colchicine really harmful in viral myocarditis?

International journal of cardiology·2016
Same author

Congenital heart block and immune mediated sensorineural hearing loss: possible cross reactivity of immune response.

Lupus·2016
Same author

Reply to: "Effusive-constrictive pericarditis successfully treated with anakinra" G. Lazaros et al. Interleukin-1β receptor antagonist and pericardial constriction.

Clinical and experimental rheumatology·2015
Same author

[A peculiar lead poisoning: a concern of team achievement].

Giornale italiano di medicina del lavoro ed ergonomia·2013
Same author

Modeling and simulation of dense cloud dispersion in urban areas by means of computational fluid dynamics.

Journal of hazardous materials·2011

Area of Science:

  • Cardiology
  • Internal Medicine
  • Pharmacology

Background:

  • Recurrent acute pericarditis presents a clinical challenge.
  • Effective long-term management strategies are crucial for improving patient outcomes.

Purpose of the Study:

  • To evaluate the efficacy of a comprehensive multidrug protocol for managing recurrent acute pericarditis.
  • To specifically determine the contribution of colchicine to treatment success.

Main Methods:

  • A monocentric observational study involving 58 patients with recurrent acute pericarditis.
  • Patients received non-steroidal anti-inflammatory drugs, with cautious corticosteroid tapering if previously used.
  • Colchicine was administered to 44 patients; 14 did not receive it. Other immunosuppressants were used as needed.

Related Experiment Videos

Main Results:

  • The protocol reduced recurrence rates from 0.48 to 0.03 attacks/patient/month within 12 months (p < 0.00001).
  • Colchicine-treated patients showed a significantly greater reduction in recurrences compared to those not receiving it (p = 0.006).
  • 16.3% of patients discontinued colchicine due to side effects, yet achieved good disease control.

Conclusions:

  • A multidrug protocol, including NSAIDs, slow corticosteroid tapering, and colchicine, is highly effective for recurrent pericarditis.
  • Colchicine significantly enhances treatment outcomes in recurrent pericarditis.
  • Even patients intolerant to colchicine can achieve substantial disease control with this protocol.