Head trauma and cluster headache
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Updated: Aug 10, 2026

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion
Published on: April 19, 2024
Gian Camillo Manzoni1, Giorgio Lambru, Paola Torelli
1Headache Centre, Department of Neurology, University of Parma and University Centre for Adaptive Disorders and Headache, Via Gramsci, 14, 43100 Parma, Italy. giancamillo.manzoni@unipr.it
Abstract:
Post-traumatic cluster headache (CH) is a very rare occurrence. Only one such case has been verified in the literature thus far. On the other hand, a non-casual association is almost certain to exist between previous head trauma and future CH onset. Considering the generally long interval of time separating the two events, it is not easy to accurately explain the nature of the head trauma/CH relationship. Head trauma may damage extra- or intracranial peripheral or central nervous structures, hence predisposing to the future development of CH. However, there also is the possibility that previous head injuries may be more frequent among CH patients because of their lifestyle, which may leave them more exposed to the risk of traumatic events.
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