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Neurophysiological reactivity before a migraine attack.

Michael Siniatchkin1, Nadejda Averkina, Frank Andrasik

  • 1Pediatric Neurology, University of Kiel, Schwanenweg 20, 24105 Kiel, Germany. m.siniatchkin@pedneuro.uni-kiel.de

Neuroscience Letters
|March 17, 2006
PubMed
Summary
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Migraine patients show heightened brain reactivity to stress before an attack. This increased susceptibility to migraine triggers, like stress, is linked to abnormal contingent negative variation (CNV) responses.

Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Psychophysiology

Background:

  • Migraine patients exhibit altered contingent negative variation (CNV) responses, particularly preceding attacks.
  • Migraine triggers can induce CNV abnormalities, but the timing relative to an attack is not fully understood.

Purpose of the Study:

  • To investigate the impact of experimentally induced stress on CNV responses in migraine patients before, during, and after a migraine attack.
  • To compare the neurophysiological stress reactivity of migraineurs with healthy individuals.

Main Methods:

  • Recording of CNV during rest and stress conditions in migraine patients and healthy controls.
  • Stress was experimentally induced via achievement tasks.
  • Recordings were taken before a migraine attack, after an attack (headache-free interval), and in healthy controls.

Related Experiment Videos

Main Results:

  • Migraine patients displayed significantly greater neurophysiological reactivity to stress before an attack compared to after an attack or in healthy controls.
  • Specifically, increased early CNV amplitude and reduced habituation were observed 1-3 days before a migraine attack under stress.
  • These stress-induced CNV changes were less pronounced after the attack or in the headache-free interval.

Conclusions:

  • The migraineurs' brains exhibit heightened susceptibility to migraine-precipitating agents, such as stress, in the period leading up to an attack.
  • This heightened reactivity, evidenced by CNV alterations, suggests a specific neurophysiological state preceding migraine onset.