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Variation in bacterial flagellins: from sequence to structure.

Scott A Beatson1, Tohru Minamino, Mark J Pallen

  • 1Division of Immunity and Infection, University of Birmingham Medical School, Vincent Drive, Edgbaston, Birmingham, UK, B15 2TT.

Trends in Microbiology
|March 17, 2006
PubMed
Summary
This summary is machine-generated.

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Bacterial flagellins, essential for motility, show conserved sequences for filament assembly but variable surface domains. This highlights evolutionary conservation and variability in bacterial flagellar structures.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Bacterial motility is crucial for survival and pathogenesis.
  • The bacterial flagellum, a molecular motor, drives motility.
  • Flagellar filaments are polymers of the protein flagellin.

Purpose of the Study:

  • To investigate flagellin sequence conservation and diversity.
  • To correlate sequence features with the known flagellar filament structure.
  • To understand the evolutionary principles governing flagellin.

Main Methods:

  • Comparative sequence analysis of flagellin proteins.
  • Examination of flagellin sequences in relation to structural data.
  • Identification of conserved and variable regions within flagellin.

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Main Results:

  • Surface-exposed domains of flagellin are highly variable.
  • Sequences mediating flagellar filament assembly are remarkably conserved.
  • A conserved mechanism for flagellin packing into filaments is suggested.

Conclusions:

  • Bacterial flagellins exemplify evolutionary trade-offs between conservation and variability.
  • Conserved assembly sequences ensure functional flagellar filament formation across species.
  • Variability in surface domains may relate to host interactions or immune evasion.