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Updated: Aug 10, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes
Yasunobu Takizawa1, Hiroko Kanda, Kojiro Sato
1Department of Allergy and Rheumatology, University of Tokyo, 7-3-1 Hongo, Tokyo, 113-8655, Japan.
Abstract:
A 58-year-old man concurrently developed polymyositis (PM), interstitial lung disease, and nephrotic-range proteinuria. Renal biopsy revealed focal mesangial proliferative glomerulonephritis (mesPGN) with depositions of immunoglobulin and complements. A combination therapy of corticosteroid, intravenous immunoglobulin, and cyclosporine was found very effective for the patient. Glomerulonephritis associated with PM/dermatomyositis (DM) is rare. In our review of related literature, mesPGN was exclusively observed in polymyositis while membranous nephropathy in DM. The mechanism underlying the association between myositis and glomerulonephritis remains to be elucidated.
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