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Related Experiment Videos

[Endogenous digitalis].

M Ortega1, V Regife, M Pérez-Cerezal

  • 1Departamento de Medicina Interna, Hospital Universitario Virgen Macarena, Sevilla.

Anales De Medicina Interna (Madrid, Spain : 1984)
|February 1, 1991
PubMed
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Researchers identified an endogenous substance that mimics digoxin effects in patients without heart medication. This substance, linked to increased plasma volume, clearly inhibits the sodium pump.

Area of Science:

  • Endocrinology
  • Cardiology
  • Biochemistry

Background:

  • Research over the last decade has focused on an endogenous substance cross-reacting with digoxin antibodies.
  • This substance has been observed in patients not receiving cardiotonic treatment.

Purpose of the Study:

  • To investigate the nature and implications of an endogenous digoxin-like substance.
  • To understand its role in clinical conditions involving plasma volume expansion.

Main Methods:

  • Utilized digoxin antibodies for immunoreaction assays.
  • Analyzed clinical cases with increased plasmatic volume.
  • Investigated molecular structure and anatomic origin.

Main Results:

  • An endogenous substance exhibiting digoxin-like immunoreactivity was identified.

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  • Its presence correlates with increased plasma volume in various clinical settings.
  • The substance's mechanism involves competitive inhibition of the sodium pump.

    • Conclusions:

    • An endogenous digoxin-like substance plays a role in conditions with elevated plasma volume.
    • Its molecular structure and sodium pump inhibitory action are well-characterized.