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Temporal relation between sleep and mood in patients with bipolar disorder
Michael Bauer1, Paul Grof, Natalie Rasgon
1Department of Psychiatry and Psychotherapy, Charité--University Medicine Berlin, Campus Charité Mitte (CCM), Berlin, Germany. michael.bauer@charite.de
Bipolar Disorders
|March 18, 2006
Summary
Changes in sleep patterns, particularly those exceeding 3 hours, often precede significant mood shifts in bipolar disorder patients by one day. Early recognition of these sleep disturbances can aid in relapse prevention.
Area of Science:
- Psychiatry
- Sleep Medicine
- Chronobiology
Background:
- Bipolar disorder management benefits from early recognition of prodromal symptoms and patient action plans to prevent relapses.
- Sleep disturbances are common warning signs for both manic and depressive episodes in bipolar disorder.
Purpose of the Study:
- To characterize the relationship between mood, sleep, and bedrest using cross-correlation analysis in longitudinal data from bipolar disorder patients.
- To determine the time latency between changes in sleep/bedrest and subsequent mood changes.
Main Methods:
- Analysis of self-reported mood, sleep, and bedrest data from 59 outpatients with bipolar disorder over a mean of 169 days.
- Application of cross-correlation function to assess time shifts (-7 to 7 days) between sleep/bedrest and mood changes.
Main Results:
- A significant inverse correlation was observed between sleep/bedrest and mood changes, typically with a one-day latency.
- Sleep and bedrest combined showed the strongest association with mood change, significantly correlating in 41% of patients on the night before or of the mood change.
- Patients with significant cross-correlations reported a higher proportion of large sleep (>3h) and mood (>20 on 100-unit scale) changes and were more likely to use benzodiazepines.
Conclusions:
- Mood changes in bipolar disorder often follow alterations in sleep and/or bedrest patterns by approximately one day.
- Significant deviations in sleep, especially exceeding 3 hours, may signal an impending major mood episode, aiding in early intervention.
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