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The nucleotide sequence, 5' end, promoter domain, and kinetics of expression of the gene encoding the herpes simplex
P R Krause1, J M Ostrove, S E Straus
1Medical Virology Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Journal of Virology
|October 1, 1991
Abstract:
The sequence of the herpes simplex virus type 2 (HSV-2) latency-associated transcript (LAT) region resembles that of HSV-1 only where the LATs overlap ICP0 and in the putative promoter region. Otherwise, the LAT 5' ends, kinetics of expression, and promoter elements are mostly conserved between HSV-1 and HSV-2. The remaining differences between the LATs could contribute to each virus's distinctive pattern of reactivation.