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Pharmacologic interventions for smoking cessation.

Robin L Corelli1, Karen Suchanek Hudmon

  • 1Department of Clinical Pharmacy, School of Pharmacy, University of California, 521 Parnassus Avenue, San Francisco, San Francisco, CA 94143, USA. corellir@pharmacy.ucsf.edu

Critical Care Nursing Clinics of North America
|March 21, 2006
PubMed
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Healthcare providers should recommend pharmacotherapy for smoking cessation to most patients. This overview covers FDA-approved and other medications to aid tobacco cessation efforts.

Area of Science:

  • Pharmacology
  • Nursing
  • Public Health

Background:

  • The US Public Health Service recommends pharmacotherapy for smoking cessation.
  • Tobacco dependence is a significant public health issue requiring effective interventions.
  • Acute and critical care nurses play a vital role in supporting patients who want to quit smoking.

Purpose of the Study:

  • To provide an overview of pharmacologic agents for smoking cessation.
  • To guide acute and critical care nurses in selecting appropriate medications for tobacco-dependent patients.
  • To discuss various classes of smoking cessation pharmacotherapies.

Main Methods:

  • Review of first-line pharmacologic agents approved by the Food and Drug Administration (FDA) for smoking cessation, including nicotine replacement therapy and sustained-release bupropion.

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  • Examination of second-line agents, such as nortriptyline and clonidine, which have demonstrated efficacy but lack FDA approval for smoking cessation.
  • Exploration of combination or high-dose therapy approaches, herbal remedies, and emerging pharmacotherapies currently under investigation.

    • Main Results:

    • First-line agents (nicotine replacement therapy, bupropion) are FDA-approved and effective for smoking cessation.
    • Second-line agents (nortriptyline, clonidine) show efficacy but are not FDA-indicated for this purpose.
    • Combination therapies, herbal options, and novel agents represent additional or future avenues for smoking cessation.

    Conclusions:

    • Pharmacotherapy is a cornerstone of smoking cessation interventions for most patients.
    • Nurses should be knowledgeable about various pharmacologic options to support tobacco cessation.
    • A range of therapeutic strategies, from FDA-approved medications to emerging treatments, can be employed to assist patients in quitting smoking.