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Natural IgE production in the absence of MHC Class II cognate help

Kathy D McCoy1, Nicola L Harris, Philipp Diener

  • 1Institute of Experimental Immunology, Department of Pathology, Universitätsspital, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland. mccoyk@pathol.unizh.ch

Immunity
|March 21, 2006
PubMed

IgE induction by parasites and allergens is antigen driven and cognate T cell help dependent. We demonstrate that spontaneously produced IgE in T cell-deficient and germ-free wild-type (wt) mice is composed of natural specificities and induced by a mechanism independent of MHC class II (MHC II) cognate help. This does not require secondary lymphoid structures or germinal center formation, although some bystander T cell-derived IL-4 is necessary. The pathway of spontaneous IgE production is not inhibited by regulatory T cells and increases with age to constitute significant serum concentrations, even in naive animals.

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