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Cellular adhesion molecules as targets for bacterial infection.
Christof R Hauck1, Franziska Agerer, Petra Muenzner
1Zentrum für Infektionsforschung, Universität Würzburg, Röntgenring 11, D-97070 Würzburg, Germany. christof.hauck@mail.uni-wuerzburg.de
European Journal of Cell Biology
|March 21, 2006
Summary
Bacterial pathogens exploit host cell adhesion molecules like integrins and immunoglobulin-related cell adhesion molecules (IgCAMs) to infect cells. This binding can lead to bacterial entry and altered host cell behavior.
Area of Science:
- Microbiology
- Cell Biology
- Immunology
Background:
- Bacterial pathogens frequently target host cell adhesion molecules for invasion.
- Integrins, cadherins, and immunoglobulin-related cell adhesion molecules (IgCAMs) are common targets.
- Bacterial binding can trigger host cell internalization and signaling.
Purpose of the Study:
- To review recent advances in understanding bacterial adhesion molecule engagement.
- To discuss specific examples of bacterial targeting of integrins and IgCAMs.
Main Methods:
- Literature review of recent scientific publications.
- Focus on Staphylococcus aureus interaction with integrins.
- Focus on pathogenic Neisseria species interaction with IgCAMs.
Main Results:
- Staphylococcus aureus binds to host cell integrins.
- Pathogenic Neisseria species exploit IgCAMs for host cell interaction.
- Bacterial engagement leads to receptor clustering, cytoskeletal changes, and host cell responses.
Conclusions:
- Bacterial pathogens utilize diverse strategies to engage host cell adhesion molecules.
- Understanding these interactions is crucial for developing novel therapeutic interventions.
- Further research will elucidate the intricate mechanisms of host-pathogen adhesion.