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In Vitro Assay of Bacterial Adhesion onto Mammalian Epithelial Cells
05:57

In Vitro Assay of Bacterial Adhesion onto Mammalian Epithelial Cells

Published on: May 16, 2011

Cellular adhesion molecules as targets for bacterial infection

Christof R Hauck1, Franziska Agerer, Petra Muenzner

  • 1Zentrum für Infektionsforschung, Universität Würzburg, Röntgenring 11, D-97070 Würzburg, Germany. christof.hauck@mail.uni-wuerzburg.de

European Journal of Cell Biology
|March 21, 2006
PubMed

Insights

Bacterial pathogens exploit host cell adhesion molecules like integrins and immunoglobulin-related cell adhesion molecules (IgCAMs) to infect cells. This binding can lead to bacterial entry and altered host cell behavior.

Area of Science:

  • Microbiology
  • Cell Biology
  • Immunology

Background:

  • Bacterial pathogens frequently target host cell adhesion molecules for invasion.
  • Integrins, cadherins, and immunoglobulin-related cell adhesion molecules (IgCAMs) are common targets.
  • Bacterial binding can trigger host cell internalization and signaling.

Purpose of the Study:

  • To review recent advances in understanding bacterial adhesion molecule engagement.
  • To discuss specific examples of bacterial targeting of integrins and IgCAMs.

Main Methods:

  • Literature review of recent scientific publications.
  • Focus on Staphylococcus aureus interaction with integrins.
  • Focus on pathogenic Neisseria species interaction with IgCAMs.

Main Results:

  • Staphylococcus aureus binds to host cell integrins.
  • Pathogenic Neisseria species exploit IgCAMs for host cell interaction.
  • Bacterial engagement leads to receptor clustering, cytoskeletal changes, and host cell responses.

Conclusions:

  • Bacterial pathogens utilize diverse strategies to engage host cell adhesion molecules.
  • Understanding these interactions is crucial for developing novel therapeutic interventions.
  • Further research will elucidate the intricate mechanisms of host-pathogen adhesion.

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