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Internet resources for phenotyping engineered rodents.

Brad Bolon1

  • 1GEMpath Inc., Cedar City, Utah, USA.

ILAR Journal
|March 21, 2006
PubMed
Summary
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Genetically engineered rodents, including mice (GEM) and rats (GER), are crucial for studying health and disease. Comprehensive genotypic and phenotypic analysis is essential for understanding engineered genes and their relevance to human conditions.

Area of Science:

  • Biomedical Research
  • Animal Models
  • Genetics

Background:

  • Genetically engineered mice (GEM) and rats (GER) are indispensable mammalian models in biomedical research.
  • These models are vital for investigating physiological (health) and pathological (disease) mechanisms.

Purpose of the Study:

  • To highlight the critical need for thorough genotypic and phenotypic characterization of novel GEM and GER.
  • To provide researchers with a starting point for identifying resources to aid in the analysis of these models.

Main Methods:

  • The study reviews existing websites and resources that offer tools for genotyping and phenotyping.
  • It focuses on describing the basic features of these online tools.

Main Results:

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  • Numerous online resources have been developed to assist researchers in the genotyping and phenotyping of GEM and GER.
  • These websites provide valuable tools for characterizing novel genetically engineered rodent models.

Conclusions:

  • Effective characterization of GEM and GER requires meticulous genotypic and phenotypic analysis.
  • Accessible online resources can significantly facilitate the process of evaluating the significance of engineered genes for human health and disease research.