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Nociceptin-induced histamine release in the brain: comparison with compound 48/80- and substance P-induced amine

K Tekes1, M Hantos, B Bizderi

  • 1Department of Pharmacodynamics, Semmelweis University, P.O. Box 370, Budapest, Hungary.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|March 21, 2006
PubMed
Abstract

No abstract available in PubMed .

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...