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Updated: Aug 9, 2026

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Advances in nitrogen transfer reactions involving aziridines
Iain D G Watson1, Lily Yu, Andrei K Yudin
1Davenport Research Laboratories, Department of Chemistry, The University of Toronto, 80 St. George Street, Toronto M5S 3H6, Ontario, Canada.
Abstract:
In recent years, our search for new nitrogen transfer reactions has concentrated on aziridine chemistry. This Account highlights our efforts toward the synthesis and functionalization of aziridines. In the course of our research, we have investigated the electrochemical aziridination of olefins, the acid-catalyzed ring opening of aziridines, and the development of transition metal mediated nitrogen allylation, arylation, and alkenylation of unprotected aziridines. Our studies have also involved the synthesis of aziridine-based enamine intermediates and their stereoselective transformations into heterocyclic compounds.
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