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Related Experiment Videos

Collapse and shedding transitions in binary lipid monolayers coating microbubbles.

Gang Pu1, Mark A Borden, Marjorie L Longo

  • 1Department of Chemical Engineering & Materials Science, University of California, Davis, California 95616, USA.

Langmuir : the ACS Journal of Surfaces and Colloids
|March 22, 2006
PubMed
Summary

We studied how lipid-coated microbubbles collapse and shed material during dissolution. Bubble shell structure and temperature influence collapse mechanisms, affecting particle shedding and bubble shape.

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Area of Science:

  • Physical Chemistry
  • Materials Science
  • Biophysics

Background:

  • Microbubbles are widely used in medical applications, such as ultrasound imaging and drug delivery.
  • Understanding microbubble dissolution is crucial for optimizing their performance and safety.
  • The behavior of lipid-coated microbubbles is influenced by the properties of their monolayer shell.

Purpose of the Study:

  • To investigate the monolayer collapse and shedding behavior of air-filled, lipid-coated microbubbles during dissolution.
  • To examine the effect of phospholipid acyl chain length and temperature on microbubble shell morphology.
  • To elucidate the mechanisms of microbubble collapse and particle shedding.

Main Methods:

  • Fluorescence microscopy was used to observe the dissolution of microbubbles.

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  • The microbubble shell composition was varied by altering phospholipid acyl chain length (C12:0 to C22:0) and temperature.
  • Morphologies of collapse structures and shed particles were analyzed.

    • Main Results:

    • Miscible phase formation above the main phase transition temperature led to collapse via suboptical particles, vesicles, and tubes.
    • Two-phase coexistence below the main phase transition temperature resulted in primary (vesiculation) and secondary collapse (fold propagation).
    • Rigid monolayers exhibited surface buckling and fold merging, facilitating rapid lipid shedding and bubble smoothing.

    Conclusions:

    • Phospholipid acyl chain length and temperature significantly dictate microbubble dissolution pathways.
    • The observed collapse mechanisms provide insights into the stability and behavior of microbubbles in various environments.
    • Findings have implications for microbubble-based medical applications and understanding natural microbubble dissolution.