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Updated: Aug 9, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
Published on: April 7, 2021
Supplemental jet ventilation in a case of ARDS complicated by bronchopleural fistulae
1Intensive Care Unit, Fremantle Hospital, Fremantle, Western Australia. david.simes@health.wa.gov.au
Objective:
To present a case of unusual ventilatory strategy in a 17 year old girl with the acute respiratory distress syndrome (ARDS) complicated by bilateral bronchopleural fistulae.
Methods:
The patient was ventilated with a combination of conventional pressure control ventilation (PCV) and high frequency jet ventilation (HFJV) for 133 and 110 days, respectively.
Results:
Despite prolonged hypoxia, extensive barotrauma and nosocomial infections, she survived without significant impairment of respiratory function. Two years later she was healthy and independent with only mildly reduced respiratory reserve.
Conclusions:
The combination of PCV and HFJV was beneficial in this case of ARDS complicated by bronchopleural fistulae. The case also highlights the utility of HFJV in the desperately hypoxic patient with extensive airway disruption.
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