Related Experiment Video
Updated: Aug 9, 2026
11:49
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Tuberculin positivity: A serious problem before transplantation in Turkey
G Kantarci1, H Altinöz, S Sahin
1Department of Nephrology, Göztepe Teaching Hospital, Istanbul, Turkey.
Transplantation Proceedings
|March 22, 2006
Summary
Tuberculosis screening is crucial for chronic renal failure (CRF) patients before transplantation. Many asymptomatic CRF patients show latent tuberculosis infection or anergy, requiring careful evaluation of medical history.
Area of Science:
- Nephrology
- Infectious Diseases
- Immunology
Background:
- Chronic renal failure (CRF) patients face a higher risk of tuberculosis (TB).
- Screening for latent tuberculosis infection (LTBI) is vital before organ transplantation.
- The tuberculin skin test (TST) is the standard method for diagnosing LTBI.
Purpose of the Study:
- To evaluate the tuberculin test status in asymptomatic CRF patients awaiting transplantation.
- To correlate TST results with patient history and laboratory values.
- To assess the prevalence of LTBI and anergy in this high-risk population.
Main Methods:
- A cohort of 164 asymptomatic CRF patients underwent tuberculin skin testing (5 Todd units).
- Anamnestic data (previous TB history, family history) and laboratory values were collected.
- Statistical analysis was used to correlate TST results with demographic and clinical factors.
Main Results:
- Tuberculin positivity was observed in 42.1% of patients, while 43.3% showed anergy.
- Skin test positivity correlated with older age (r = .294, P = .0001).
- Peritoneal dialysis patients had higher rates of anergy, whereas pre-transplant patients showed higher positivity (P = .009).
Conclusions:
- A significant prevalence of both tuberculin positivity and anergy exists among asymptomatic pre-transplant CRF patients.
- Thorough evaluation of TB history and family history is recommended for CRF patients awaiting transplantation.
- Elderly CRF patients represent a higher-risk group for purified protein derivative (PPD) positivity.
Related Concept Videos
01:26Pulmonary Tuberculosis IV
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
01:29Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:31Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
01:24Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
01:28Pulmonary Tuberculosis V
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...