Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cancer stem cells.

Wei Guo1, Joseph L Lasky, Hong Wu

  • 1Department of Molecular and Medical Pharmacology, University of California, Los Angeles, 90095, USA. wguo@mednet.ucla.edu

Pediatric Research
|March 22, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An allosteric inhibitor of protein arginine methyltransferase 3.

Structure (London, England : 1993)·2012
Same author

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

Cancer cell·2012
Same author

Cell intrinsic role of COX-2 in pancreatic cancer development.

Molecular cancer therapeutics·2012
Same author

Loss of the androgen receptor cofactor p44/WDR77 induces astrogliosis.

Molecular and cellular biology·2012
Same author

JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.

Proceedings of the National Academy of Sciences of the United States of America·2012
Same author

Incidence of invasive squamous cell carcinomas in biopsy-proven squamous cell carcinomas in situ sent for Mohs micrographic surgery.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2012
Same journal

Beyond recognition: advancing early prediction of pediatric sepsis.

Pediatric research·2026
Same journal

Co-exposure to cannabinoids and nicotine increases senescence in prenatal human lung development.

Pediatric research·2026
Same journal

Developmental outcomes in infants treated with therapeutic hypothermia before and during the COVID-19 pandemic.

Pediatric research·2026
Same journal

Choice, confounding, and consequence: twenty years of empiric antibiotics for neonatal early-onset sepsis.

Pediatric research·2026
Same journal

Comparing in-person and online recruitment methods in a prospective pediatric cohort study.

Pediatric research·2026
Same journal

Craniosynostosis and neurodevelopment: reframing a surgical condition as a global developmental risk.

Pediatric research·2026
See all related articles

Cancer stem cells (CSCs) initiate tumors and drive resistance. Understanding CSCs, which share traits with normal stem cells, is key to new cancer therapies.

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Cancer Research

Background:

  • Cancer stem cells (CSCs) are proposed as the key drivers of tumorigenesis and cancer resistance.
  • CSCs have been identified in various cancers, including leukemia, breast, brain, and lung tumors.
  • CSCs share characteristics with normal stem cells, such as rarity, quiescence, self-renewal, and tumor growth maintenance.

Purpose of the Study:

  • To explore the origin and molecular alterations of cancer stem cells.
  • To highlight the significance of understanding CSCs for future cancer research and treatment.
  • To discuss the potential of CSCs in re-classifying human tumors and developing targeted therapies.

Main Methods:

  • Review of existing literature on cancer stem cell identification and characterization.

Related Experiment Videos

  • Comparative analysis of CSC properties with normal stem cell biology.
  • Molecular pathway analysis related to stem cell self-renewal in cancer transformation.

    • Main Results:

    • CSCs are rare, quiescent, and possess self-renewal capabilities, driving tumor growth and heterogeneity.
    • CSCs may originate from normal stem cells, progenitor cells, or even cells from other tissues.
    • Alterations in stem cell self-renewal pathways are crucial for CSC transformation.

    Conclusions:

    • A deeper understanding of CSCs is essential for advancing cancer research.
    • Targeting CSCs offers a promising avenue for novel therapeutic strategies.
    • CSCs may necessitate a re-classification of human tumors based on their unique biology.