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Updated: Aug 9, 2026

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
Published on: October 15, 2013
Interferon-gamma decreases replication of primary R5 HIV-1 isolates in thymocytes
Livia Pedroza-Martins1, W John Boscardin, Deborah J Anisman-Posner
1Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095-1747, USA.
Abstract:
As interferon-gamma (IFN-gamma) is produced at lower levels by neonatal than adult T cells, we determined whether IFN-gamma influences HIV-1 replication in thymocytes. IFN-gamma significantly decreased replication of R5 but not X4 viruses, and reduced depletion of CD3(hi)CD27 (mature) thymocytes, the preferential targets for R5 HIV-1. Thus infection and depletion of functionally mature thymocytes that can produce endogenous IFN-gamma may mutually contribute to HIV-1 replication in the thymus and to reduced T-cell output.
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