Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alcohol and the liver.

Adrian Reuben1

  • 1Liver Service, Division of Gastroenterology/Hepatology and Liver Transplant Program, Medical University of South Carolina, Charleston, 29425, USA. reubena@musc.edu

Current Opinion in Gastroenterology
|March 22, 2006
PubMed
Summary

Advances in alcoholic liver disease (ALD) research reveal new genetic factors and immune system roles. While prognosis is better understood, effective treatments for alcoholic hepatitis and cirrhosis remain elusive.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and pathological spectrum of disease severity among patients with acute liver failure (ALF) undergoing deceased donor liver transplantation.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2025
Same author

Differentiating Ischemic Hepatitis from Acetaminophen Overdose in Acute Liver Failure: Role of Acetaminophen Adducts-Ischemic Hepatitis vs Acetaminophen Overdose.

Digestive diseases and sciences·2024
Same author

The liver in Judaism.

Clinical liver disease·2024
Same author

Indeterminate etiology of acute liver failure in North America: Less common, still grave prognosis.

Clinical transplantation·2023
Same author

Autoimmune hepatitis presenting as acute liver failure: A 20-year retrospective review of North America.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2023
Same author

GI multisociety strategic plan on environmental sustainability.

Gastrointestinal endoscopy·2022

Area of Science:

  • Hepatology
  • Immunology
  • Genetics

Background:

  • Alcoholic liver disease (ALD) remains a significant global health burden, despite declining alcohol consumption in some regions.
  • Understanding ALD's epidemiology, pathogenesis, prognosis, and treatment is crucial for public health.

Purpose of the Study:

  • To review recent advancements in 2005 concerning the epidemiology, pathogenesis, prognosis, and treatment of alcoholic liver disease.
  • To highlight key findings in genetic mechanisms, cofactors, immune system involvement, and therapeutic strategies for ALD.

Main Methods:

  • Review of recent scientific literature published up to 2005.
  • Synthesis of findings related to genetic factors, cofactors, immune responses, and clinical outcomes in ALD.
  • Evaluation of prognostic models and treatment approaches for alcoholic hepatitis and cirrhosis.

Main Results:

  • Discovery of genetic mechanisms underlying ALD and identification of aggravating (e.g., hepatitis C, obesity) and ameliorating (e.g., coffee, tea) cofactors.
  • Enhanced understanding of the innate immune system's role and apoptosis mechanisms, including the significance of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
  • Refined understanding of steroid use and nutrition in alcoholic hepatitis, validated prognostic utility of the Model for End-Stage Liver Disease (MELD) score, and confirmed adverse impact of recidivism on liver transplant outcomes.

Conclusions:

  • Significant progress has been made in understanding the genetic underpinnings and pathogenetic pathways of ALD.
  • Despite new insights, safe and effective therapeutic interventions for alcoholic hepatitis and alcoholic cirrhosis are still needed.

Related Experiment Videos