Related Experiment Video
Updated: Aug 9, 2026

Flow Cytometry Analysis of Immune Cells Within Murine Aortas
Published on: July 1, 2011
[Immunological aspects of atherosclerosis]
Emilie Groyer1, Giuseppina Caligiuri, Jamila Laschet-Khallou
1Inserm U681, Université Pierre et Marie Curie - Paris VI, Institut des Cordeliers.
Abstract:
The pathogenesis of atherosclerosis remains incompletely understood. Accumulation of oxidized lipoproteins (oxLDL) within the vascular wall drives a related immune response very early during the disease course. Such an immune response is self-amplified and eventually escapes from physiologic control mechanisms. Certain lymphocytes may become pathogenic. B cells play a protective role by producing antibodies able to neutralize oxLDL. Elucidation of the immune control mechanisms in atherosclerosis will open the way to new therapeutic perspectives.
Related Concept Videos
Atherosclerosis I: Introduction
Inflammation
Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease I: Introduction
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Atherosclerosis III: Management

