Related Experiment Video
Updated: Aug 9, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Insights
Vitamin D deficiency and rickets are rising public health issues, especially in UK infants and children from ethnic minorities. Management strategies for primary vitamin D deficiency in children are discussed.
Area of Science:
- Nutritional Science
- Pediatrics
- Public Health
Background:
- Increasing prevalence of vitamin D deficiency and re-emergence of rickets in developed countries.
- Specific at-risk populations include infants, toddlers, and adolescents from ethnic minority groups (Asian, African Caribbean, Middle Eastern).
- Exclusively breast-fed infants without supplements and infants of mothers with inadequate prenatal vitamin D intake are also at high risk.
Purpose of the Study:
- To discuss the management of primary vitamin D deficiency in children.
- To highlight the public health problem of re-emerging rickets.
- To identify key risk factors and populations for vitamin D deficiency.
Main Methods:
- Review and discussion of clinical management strategies for primary vitamin D deficiency.
- Identification of at-risk populations based on ethnicity, feeding practices, and maternal health.
- Focus on nutrient deficiency as the cause of vitamin D deficiency.
Main Results:
- Vitamin D deficiency and rickets are significant public health concerns.
- Certain ethnic minority groups and infants with specific feeding/maternal histories are disproportionately affected.
- Primary vitamin D deficiency requires targeted management approaches.
Conclusions:
- Effective management strategies are crucial for addressing the rise in childhood vitamin D deficiency and rickets.
- Public health initiatives should focus on identified at-risk populations.
- Ensuring adequate vitamin D intake during infancy and pregnancy is essential.
Abstract:
In recent years, the prevalence of vitamin D (calciferol) deficiency has increased and rickets has re-emerged in the UK and other developed countries as a public health problem. Infants, toddlers and adolescents in 'at risk' ethnic minorities (e.g. Asian, African Caribbean and Middle Eastern) are particularly likely to be vitamin D-deficient or to have rickets. Also at particular risk are babies and toddlers who have been exclusively breast-fed during infancy without receiving vitamin supplements, or whose mothers did not have vitamin D supplements during pregnancy. Here we discuss the management of children with primary vitamin D deficiency (i.e. that due to nutrient deficiency).
Related Concept Videos
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Vitamins
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Introduction to Electrolytes
Role of Sodium
One...
Skeleton and Calcium Homeostasis
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...