Related Experiment Video

Updated: Aug 9, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Bone marrow diffusion measures correlate with dementia severity in HIV patients

A B Ragin1, Y Wu, P Storey

  • 1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA.

AJNR. American Journal of Neuroradiology
|March 23, 2006
PubMed
Abstract

Insights

Quantitative imaging reveals reduced bone marrow diffusion in HIV patients, correlating with dementia severity. This finding highlights diffusion imaging as a tool for monitoring HIV-associated neurologic progression.

Area of Science:

  • Neuroimaging
  • Hematology
  • Infectious Diseases

Background:

  • Monocyte trafficking from bone marrow to the brain contributes to central nervous system injury in HIV.
  • Cognitive deterioration in HIV patients may be linked to bone marrow changes.

Purpose of the Study:

  • To test if mean diffusivity (MD) is sensitive to bone marrow changes in HIV patients.
  • To determine if quantitative imaging measurements correlate with dementia severity in HIV.

Main Methods:

  • Compared mean diffusivity (MD) in clival and calvarial marrow between 11 HIV patients and 9 controls.
  • Evaluated imaging measurements against dementia severity, CD4 counts, and plasma viral load.

Main Results:

  • HIV patients showed significantly reduced MD in both clival and calvarial marrow (P =.006).
  • Diffusion measurements in clival (P =.02) and calvarial (P =.03) marrow correlated significantly with dementia severity.

Conclusions:

  • Diffusion imaging strategies are useful for monitoring bone marrow status.
  • Results support a link between bone marrow changes and neurologic progression in HIV patients.

More Related Videos

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...