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Bone marrow diffusion measures correlate with dementia severity in HIV patients
1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA.
AJNR. American Journal of Neuroradiology
|March 23, 2006
Summary
Quantitative imaging reveals reduced bone marrow diffusion in HIV patients, correlating with dementia severity. This finding highlights diffusion imaging as a tool for monitoring HIV-associated neurologic progression.
Area of Science:
- Neuroimaging
- Hematology
- Infectious Diseases
Background:
- Monocyte trafficking from bone marrow to the brain contributes to central nervous system injury in HIV.
- Cognitive deterioration in HIV patients may be linked to bone marrow changes.
Purpose of the Study:
- To test if mean diffusivity (MD) is sensitive to bone marrow changes in HIV patients.
- To determine if quantitative imaging measurements correlate with dementia severity in HIV.
Main Methods:
- Compared mean diffusivity (MD) in clival and calvarial marrow between 11 HIV patients and 9 controls.
- Evaluated imaging measurements against dementia severity, CD4 counts, and plasma viral load.
Main Results:
- HIV patients showed significantly reduced MD in both clival and calvarial marrow (P =.006).
- Diffusion measurements in clival (P =.02) and calvarial (P =.03) marrow correlated significantly with dementia severity.
Conclusions:
- Diffusion imaging strategies are useful for monitoring bone marrow status.
- Results support a link between bone marrow changes and neurologic progression in HIV patients.
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