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Updated: Aug 9, 2026

Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen
Jesse Wells1, Constantine G Haidaris, Terry W Wright
1Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Box 690, 601 Elmwood Ave., Rochester, NY 14642, USA.
Abstract:
Mice immunized with recombinant mouse Pneumocystis carinii antigen A12-thioredoxin fusion protein developed an antibody response that recognized P. carinii antigens, as determined by Western blotting and immunofluorescence analysis. Compared to mice immunized with thioredoxin alone, mice immunized with A12-thioredoxin had significantly reduced lung P. carinii burdens after CD4+ T-cell depletion and challenge with P. carinii.
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