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Updated: Aug 3, 2026

Determination of the Gas-phase Acidities of Oligopeptides
Published on: June 24, 2013
Solid-state IR-LD spectroscopic and theoretical analysis of glycine-containing peptides and their hydrochlorides
Bojidarka B Ivanova1, Tsonko Kolev, Sonya Y Zareva
1Sofia University, St. Kl. Ohridsky,Faculty of Chemistry,1164 Sofia, Bulgaria. ahbi@chem.uni-sofia.bg
Abstract:
As part of an investigation on the coordination ability of peptides, structural analyses of the solid di-, tri, and tetrapeptides glycyl-glycine (GG), glycyl-glycyl-glycine (GGG), glycyl-glycyl-glycyl-glycine (GGGG), and their protonated hydrochlorides glycyl-glycine.HCl (GGH), glycyl-glycyl-glycine.HCl (GGGH), and glycyl-glycyl-glycyl-glycine.HCl (GGGGH) have been carried out. The quantum chemical calculations (Hartree-Fock/6-31++G**) and linear-dichroic infrared (IR-LD) spectroscopy predict a near to linear structure of the pure ligands, but the experimental IR-LD data are in accordance with a cross-linked disposition of amide fragments in the protonated forms.

