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Updated: Aug 9, 2026

Osteoclast Derivation from Mouse Bone Marrow
Published on: November 6, 2014
Osteoclast and its roles in calcium metabolism and bone development and remodeling
Zhenpeng Li1, Kangmei Kong, Weili Qi
1Department of Orthopedics, The Second Affiliated Hospital, Shantou University Medical Collage, Shantou, Guangdong 515041, China. zpli1242@sina.com
Abstract:
Osteoclasts are multinucleated cells responsible for bone resorption and play important roles in normal skeletal development, in the maintenance of its integrity throughout life, and in calcium metabolism. During bone resorption, the cytoskeleton of osteoclasts undergoes extensive reorganization, with polarization and formation of ruffled borders to secrete acid and formation of sealing zone to prevent leakage. The differentiation and function of osteoclasts are in turn regulated by osteoblasts, stromal cells, and bone. They are also subjected to negative feedback regulation by extracellular and intracellular calcium concentrations.
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