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Related Experiment Videos

Total body screening: predicting actionable findings.

Nancy Obuchowski1, Michael T Modic

  • 1Division of Radiology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. nobuchow@bio.ri.ccf.org

Academic Radiology
|March 24, 2006
PubMed
Summary
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Total body screening yields more actionable findings in older individuals. Age is the primary predictor, with the likelihood of actionable findings increasing significantly with age, especially for those over 40.

Area of Science:

  • Radiology and Medical Imaging
  • Preventive Medicine
  • Health Screening

Background:

  • Total body screening is increasingly popular but lacks clinical trial evaluation.
  • Identifying appropriate target populations for screening remains unaddressed.

Purpose of the Study:

  • To determine demographic and medical history predictors of actionable findings in total body screening.
  • To identify the optimal target demographic for maximizing screening yield.

Main Methods:

  • 982 self-referred subjects underwent total body screening using multislice computed tomography.
  • Demographic and medical history data were collected and analyzed using statistical methods.
  • Predictive models for actionable findings were developed and validated on training and testing samples.

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Main Results:

  • Age was the most significant predictor of actionable findings.
  • Actionable findings increased with age, from 22.5% in those <40 to 80% in those ≥80.
  • Each 10-year increase in age correlated with a 1.6-fold increase in actionable finding likelihood.

Conclusions:

  • Total body screening demonstrates the highest yield in older populations.
  • Further research is needed to assess the efficacy and cost-effectiveness of screening older individuals.