Synthesis of L- and D-beta-3'-Deoxy-3',3'-difluoronucleosides
Xiu-Hua Xu1, Xiao-Long Qiu, Xingang Zhang
1Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Lu, Shanghai 200032, China.
The Journal of Organic Chemistry
|March 25, 2006
Abstract:
Both L- and D-beta-3'-deoxy-3',3'-difluoronucleosides were synthesized starting from the key intermediate difluorohomoallyl alcohol 11. Deoxo-Fluor was accidentally found to be efficient in reversing the hydroxyl configuration of 34, and the desired product 41 was provided in good yield.
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