Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecular target therapy for synovial sarcoma.

Chikako Fukukawa1, Yusuke Nakamura, Toyomasa Katagiri

  • 1Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Future Oncology (London, England)
|March 25, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Importin α characterizes a micronuclear environment associated with genomic instability in human cancer cells.

Journal of cell science·2026
Same author

A one-step, resin-compatible Cys-Trp cross-linking system opens a new avenue for stapled peptide therapeutics.

Bioorganic & medicinal chemistry·2026
Same author

Crucial roles of GALNT6-mediated O-glycosylation of GRP78/Bip in proliferation of breast cancer cells.

Biochemical and biophysical research communications·2025
Same author

Targeting Interleukin-6 as a Novel Strategy to Overcome Eribulin Resistance in Breast Cancer.

Cancer medicine·2025
Same author

Efficiency of genome editing using modified single-stranded oligodeoxyribonucleotides in human cells.

Scientific reports·2025
Same author

The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis.

EMBO reports·2024

Synovial sarcoma (SS) tumorigenesis remains unclear. Gene expression suggests SS originates from neural crest cells, with Frizzled homolog 10 identified as a potential therapeutic target for SS proliferation.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The specific chromosomal translocation and SYT-SSX fusion gene in synovial sarcoma (SS) are known, but the molecular mechanisms driving its development are not fully understood.
  • Synovial sarcoma is a soft-tissue tumor.
  • Neural crest cells are a potential cell of origin for SS.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying synovial sarcoma tumorigenesis.
  • To identify genes specifically upregulated in SS that contribute to tumor cell proliferation.
  • To explore potential therapeutic targets for synovial sarcoma.

Main Methods:

  • Gene-expression profiling using cDNA microarray analysis of soft-tissue tumors.
  • Comparative analysis of gene-expression patterns between SS and other sarcomas, including malignant peripheral nerve sheath tumors.

Related Experiment Videos

  • Identification and validation of upregulated genes in SS.

    • Main Results:

    • Synovial sarcoma exhibits a distinct gene-expression pattern compared to other sarcomas.
    • The gene-expression pattern of SS is similar to that of malignant peripheral nerve sheath tumors, suggesting a neural crest origin.
    • Several genes were found to be specifically upregulated in SS, implicating them in SS cell proliferation.
    • Frizzled homolog 10 was identified as a significantly upregulated gene in SS.

    Conclusions:

    • Synovial sarcoma likely originates from neural crest cells.
    • Frizzled homolog 10 is a key molecule involved in SS cell proliferation.
    • Frizzled homolog 10 represents a promising molecular target for developing novel therapies for synovial sarcoma.