Neuraminidase of Pasteurella multocida
W Scharmann1, R Drzeniek, H Blobel
1Institut für Bakteriologie und Immunologie und Institut für Virologie, Justus Liebig-Universität, 63 Giessen, Frankfurter Strasse 87, West Germany.
Infection and Immunity
|March 1, 1970
Summary
Most Pasteurella multocida strains and some Pasteurella hemolytica strains produce neuraminidase. This enzyme may play a role in the pathogenesis of these important animal pathogens.
Area of Science:
- Microbiology
- Veterinary Medicine
- Enzymology
Background:
- Pasteurella multocida and Pasteurella hemolytica are significant bacterial pathogens in veterinary medicine.
- Neuraminidase is an enzyme that cleaves sialic acids, potentially contributing to bacterial virulence.
Purpose of the Study:
- To investigate the production of neuraminidase by strains of Pasteurella multocida and Pasteurella hemolytica.
- To determine the prevalence of neuraminidase-producing strains within these species.
Main Methods:
- Bacterial culture and isolation of Pasteurella multocida and Pasteurella hemolytica strains.
- Enzyme assays to detect neuraminidase activity in bacterial isolates.
Main Results:
- Neuraminidase activity was detected in 102 out of 104 Pasteurella multocida strains examined.
- Neuraminidase was also produced by 3 out of 5 Pasteurella hemolytica strains.
Conclusions:
- The majority of Pasteurella multocida strains possess neuraminidase activity.
- A significant proportion of Pasteurella hemolytica strains also produce this enzyme.
- Neuraminidase production is a common characteristic in these Pasteurella species, suggesting its potential role in disease.
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