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Role of complement during experimental Candida infection in mice
1Department of Medical Microbiology, Stanford University, Stanford, California 94305.
Infection and Immunity
|April 1, 1971
Summary
The study found that mice with a functional complement system survived longer during Candida albicans infections compared to those lacking complement. This highlights complement
Area of Science:
- Immunology
- Mycology
- Infectious Diseases
Background:
- Candida albicans is a common fungal pathogen.
- The role of the complement system in antifungal immunity is not fully understood.
Purpose of the Study:
- To investigate the role of the complement system in host defense against experimental Candida albicans infection.
Main Methods:
- Experimental infection of mice with Candida albicans.
- Comparison of survival rates between complement-positive and complement-deficient mice.
Main Results:
- Complement-positive mice survived significantly longer than complement-deficient mice.
- This suggests a protective role for complement in systemic candidiasis.
Conclusions:
- The complement system, particularly late-acting components, plays a crucial role in host defense against Candida albicans.
- Targeting complement may be a therapeutic strategy for invasive fungal infections.
