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Serum dexamethasone levels after decadron phonophoresis
H Darrow1, S Schulthies, D Draper
1Department of Physical Education, Brigham Young University, Provo, UT.
Journal of Athletic Training
|March 25, 2006
Summary
Decadron phonophoresis did not yield detectable serum dexamethasone levels in healthy students. Further research is required to confirm the effectiveness of this treatment method for systemic absorption.
Area of Science:
- Pharmacology
- Dermatology
- Physical Therapy
Background:
- Phonophoresis is a method for delivering medication through the skin using ultrasound.
- Dexamethasone is a potent corticosteroid used to reduce inflammation.
Purpose of the Study:
- To measure serum dexamethasone levels following phonophoresis.
- To assess systemic absorption of dexamethasone via phonophoresis.
Main Methods:
- A randomized controlled trial with 40 healthy college students.
- Dexamethasone or placebo gel was applied to the forearm, followed by ultrasound treatment.
- Serum samples were collected before and after treatment, with subsequent draws at 15 and 30 minutes.
Main Results:
- No significant serum dexamethasone levels were detected in any of the collected samples.
- The study was discontinued due to the absence of detectable drug levels.
Conclusions:
- Dexamethasone phonophoresis, as administered in this study, did not lead to measurable systemic levels of the drug.
- The efficacy of dexamethasone phonophoresis for achieving systemic absorption requires further investigation.
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