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Updated: Jan 4, 2026
Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
[Clinical analysis of histocytic necrotizing lymphadenitis]
Min-fei Pei1, Xiao Zhu, Guang-sen Zhang
1Department of Hematology,Second Xiangya Hospital, Central South University, Changsha 410011, China. peiminfei@tom.com
Objective:
To understand the clinical features and histopathology of histocytic necrotizing lymphadenitis (HNL) so as to better recognize the disease.
Methods:
The clinical features, histopathology, and diagnosis of 10 patients admitted to our hospital were retrospectively analyzed.
Results:
The clinical features of these 10 cases included: young females were the majority; lymphadenopathy and fever were the most common clinical manifestations; some cases were accompanied by connective tissue diseases. Histopathologic examination showed distinctive necrosis and around the necrotic foci, variable proliferations of histocytes but generally without infiltration of neutrophils.
Conclusion:
HNL has some typical histopathological alterations and relatively fine prognosis,but it tends to be misdiagnosed as lymphoma or lymphoid tuberculosis and may be accompanied by other diseases.
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