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Polyneuropathy as initial manifestation of necrotizing vasculitis and gangrene in systemic lupus erythematosus
H M Markusse1, T M Vroom, A H Heurkens
1Department of Rheumatology, Dr. Daniel den Hoed Clinic, Rotterdam, The Netherlands.
The Netherlands Journal of Medicine
|June 1, 1991
Abstract:
A patient with necrotizing vasculitis and systemic lupus erythematosus is reported. The vasculitis presented as a symmetrical sensorimotor axonal neuropathy and after three months it resulted in gangrene of a toe. Sural nerve conduction was abnormal and a biopsy of this nerve was diagnostic. Serum anti-endothelial cell antibodies were elevated during activity of the vasculitic process. Treatment with prednisone and cyclophosphamide induced a remission.