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Updated: Aug 9, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
A facile and efficient direct aldol addition of simple thioesters
Julianne M Yost1, Guoqiang Zhou, Don M Coltart
1Department of Chemistry and the Center for Chemical Biology, Duke University, Durham, North Carolina 27708, USA.
Abstract:
[reaction: see text] Simple thioesters undergo direct aldol addition to aldehydes in the presence of MgBr(2).OEt(2) and i-Pr(2)NEt using untreated, reagent-grade CH(2)Cl(2) under atmospheric conditions. The reactions proceed extremely rapidly and in excellent yield.
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