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Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue
Paul A Wender1, Michael K Hilinski, Nicolas Soldermann
1Departments of Chemistry and Molecular Pharmacology, Stanford University, Stanford, California 94305-5080, USA. wenderp@stanford.edu
Organic Letters
|March 28, 2006
Abstract:
[reaction: see text] A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.