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Updated: Aug 9, 2026
Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
Published on: October 24, 2018
Initial European clinical experience with pulsatile extracorporeal membrane oxygenation
Salvatore Agati1, Carmelo Mignosa, Giuseppe Ciccarello
1Pediatric Cardiac Surgery Unit, San Vincenzo Hospital, Taormina, Italy. sasha.agati@tiscali.it
Background:
Extracorporeal membrane oxygenation (ECMO) for post-cardiotomy heart failure in neonates and infants still carries high mortality and morbidity rates. In this study we present the first European clinical experience with the Medos DeltaStream DP1, a new pulsatile flow pump, in neonates and infants.
Methods:
The DP1 is an extracorporeal rotary blood pump. The pump features a diagonal flow impeller, and can be used for both continuous and pulsatile output. Special characteristics include its small priming volume of approximately 30 ml and a high pumping capacity. A temperature sensor and speed sensors are integrated into the pump. The pump has a delivery rate of up to 8 liters/min and a speed range of 100 to 10,000 rpm.
Results:
Two patients being assisted with the pulsatile pump system were successfully weaned after 36 and 53 hours, respectively.
Conclusions:
Based on our limited experience with 2 patients, we believe that pulsatile DP1 device is a reasonable alternative to current conventional non-pulsatile systems.
