Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toxic anterior segment syndrome.

Nick Mamalis1, Henry F Edelhauser, Daniel G Dawson

  • 1John A. Moran Eye Center, Department of Ophthalmology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA. nick.mamalis@hsc.utah.edu

Journal of Cataract and Refractive Surgery
|March 28, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimated Medicare Part D Ocular Drug Savings with a Direct-to-Consumer Pharmacy.

Ophthalmology·2026
Same author

Real-world data on toxic anterior segment syndrome.

Journal of cataract and refractive surgery·2026
Same author

Long-Term Implant Cytology Evaluation of Explanted Intraocular Lenses Manufactured from Different Materials.

Journal of cataract and refractive surgery·2026
Same author

Assessment of calcification presence in hydrophilic acrylic phakic intraocular lenses.

Journal of cataract and refractive surgery·2026
Same author

Comment on: Intraocular ointment after phacoemulsification.

Journal of cataract and refractive surgery·2025
Same author

Unanswered questions regarding the pathogenesis of late onset posterior capsular opacification.

Frontiers in ophthalmology·2025

Toxic anterior segment syndrome (TASS) is a sterile inflammatory reaction after eye surgery, caused by noninfectious substances damaging intraocular tissues. Identifying the toxic cause is crucial for managing TASS outbreaks and preventing recurrence.

Area of Science:

  • Ophthalmology
  • Ophthalmic Surgery
  • Toxicology

Background:

  • Toxic anterior segment syndrome (TASS) is a sterile, noninfectious postoperative inflammation affecting the anterior segment of the eye.
  • It typically manifests 12-48 hours post-cataract or anterior segment surgery and is characterized by Gram stain and culture-negative results.
  • The primary differential diagnosis for TASS is infectious endophthalmitis.

Purpose of the Study:

  • To review the literature on the causes and management of Toxic anterior segment syndrome (TASS).
  • To highlight TASS as an environmental and toxic control issue requiring thorough investigation of surgical materials and protocols.

Main Methods:

  • Literature review of reported causes and clinical characteristics of TASS.
  • Analysis of potential causative agents including intraocular solutions, preservatives, ophthalmic viscosurgical devices, detergents, endotoxins, and surgical instrument residues.

Related Experiment Videos

  • Examination of factors related to intraocular lenses, such as polishing or sterilizing compound residues.

    • Main Results:

    • TASS results from toxic damage to intraocular tissues due to noninfectious substances introduced during surgery.
    • Identified potential causes include improperly composed intraocular solutions, denatured OVDs, enzymatic detergents, bacterial endotoxins, and metal residues.
    • Factors associated with intraocular lenses, like polishing or sterilization residues, are also implicated.

    Conclusions:

    • TASS is a preventable condition linked to the surgical environment and materials.
    • Outbreaks necessitate a comprehensive analysis of all surgical fluids, medications, and sterilization protocols.
    • Effective management involves prompt steroid treatment and rigorous identification of the toxicological source.